The periaqueductal gray and descending pain modulation: why should we study them and what role do they play in chronic pain?

نویسندگان

  • Kasey S Hemington
  • Marie-Andrée Coulombe
چکیده

In this Neuro Forum we discuss the significance of a recent study by Yu et al. (Neuroimage Clin 6: 100-108, 2014). The authors examined functional connectivity of a key node of the descending pain modulation pathway, the periaqueductal gray (PAG), in chronic back pain patients. Altered PAG connectivity to pain-related regions was found; we place results within the context of recent literature and emphasize the importance of understanding the descending component of pain in pain research.

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منابع مشابه

Neuro Forum The periaqueductal gray and descending pain modulation: why should we study them and what role do they play in chronic pain?

Hemington KS, Coulombe MA. The periaqueductal gray and descending pain modulation: why should we study them and what role do they play in chronic pain? J Neurophysiol 114: 2080–2083, 2015. First published February 11, 2015; doi:10.1152/jn.00998.2014.—In this Neuro Forum we discuss the significance of a recent study by Yu et al. (Neuroimage Clin 6: 100–108, 2014). The authors examined functional...

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The periaqueductal gray and descending pain modulation : Why should we 1 study them and what role do they play in chronic pain ? 2 Running head : Periaqueductal gray connectivity in chronic pain 3

K.S.H. and M.A.C. drafted manuscript; K.S.H. and M.A.C. edited and 8 revised manuscript; K.S.H. and M.A.C. approved final version of manuscript; 9 K.S.H. and M.A.C. prepared figures. 10 11 Corresponding Author: 12 Kasey Hemington 13 [email protected] 14 Toronto Western Hospital 15 Main Pavilion 16 14th Floor Room 14MP301 17 399 Bathurst St. 18 Toronto, Ontario 19 Canada M5T 2S8 20 (41...

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عنوان ژورنال:
  • Journal of neurophysiology

دوره 114 4  شماره 

صفحات  -

تاریخ انتشار 2015